Description
Product Characteristics:
Collagen proteins (products of the COL gene family) are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. The Collagen Type XXV precursor produces the proteolytic fragment CLAC (collagenous Alzheimer amyloid plaque component), which deposits in senile plaques associated with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease. CLAC binds to the fibrillized form of Abeta, which disturbs the structure and function of plasma membranes.
Subcellular location: Secreted, Cell membrane
Synonyms: Alzheimer disease amyloid associated protein, AMY, CLAC, CLAC P, CLAC precursor, COL25A1, COL25A1 protein, Collagen alpha 1 XXV chain, Collagen alpha 1XXV chain, Collagen like Alzheimer amyloid plaque component, Collagen like Alzheimer amyloid plaque component precursor, Collagen type XXV alpha 1, Collagenous Alzheimer amyloid plaque component.
Target Information: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]